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KMID : 0358619770110010037
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Korean Journal of Physiology
1977 Volume.11 No. 1 p.37 ~ p.44
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Effects of Na Restriction, K Supplement and Diuresis on Aldosterone Metabolic Clearance in the Normal Korean
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Abstract
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In the previous study of the release,. excretion, and plasma concentration of aldosterone in normal Koreans, the author found that urinary aldosterone excretion and aldosterone secretion rate of the Korean who usually take high amount of salt are significantly lower, in compared to Americans, although the plasma concentration is only tended to be low. The control of plasmaaldosterone level depends on the secretion rate and the metabolic clearance of the hormone. In this experiments, the metabolic clearance rate of aldosterone was determined in normotensive Korean and the effects of adrenal stimulations on the rates were also studied in the same ubjects. The ; metabolic. clearance rate of the normal Korean was not significantly .different from those of the American, and shown a little increase in response to sodium restriction. These results indicate, that the decrease in secretion rate rather than the increase in metabolic clearance rate, is the major factor maintaining lower plasma aldosterone level. After furosemide diuresis, . - on the contrary, the removal of aldosterone.showed significant the decrease despite slight increase . - of secretion rate. This, suggest that the reduction in metabolic clearance rate of the hormone during volume depletion found to be major cause. of high plasma concentration. Additional, potassium supply produced; detectable decrease of metabolic clearance rate, but the. changes were smaller than that . of secretion rate,. which suggested that the higher secretion rate, could account for, elevated plasmaa concentration. of aldosterone rather than, metabolic clearance.. Above results also support author´s previous evidences that, the normal Korean.. who already adapted. to a high sodium diet have ability to produce adequate aldosterone activity without- producing. detectable changes on the metabolic´ clearance´ rate under the, condition :of,. sodium restriction with appropriate potassium intake.
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